Intracellular MR Contrast Agents Based on Cationic Cell Penetrating Peptides: A Comparative Study
نویسندگان
چکیده
J. Engelmann, W. Su, D. Jha, R. Mishra, J. Pfeuffer, K. Ugurbil High Field MR Centre, Max Planck Institute for Biological Cybernetics, Tuebingen, Baden-Wuerttemberg, Germany, Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Tuebingen, Baden-Wuerttemberg, Germany, MREA Neuro, Siemens Medical Solutions, Erlangen, Bayern, Germany, Radiology, Neurosciences, and Medicine, Center for Magnetic Resonance Research, Minneapolis, Minnesota, United States
منابع مشابه
Intracellular MR Contrast Agents based on l-Tat and d-Tat: A Comparative Study Category: Multifunctional probes
Intracellular MR Contrast Agents based on l-Tat and d-Tat: A Comparative Study Category: Multifunctional probes Ritu Mishra, Joern Engelmann, Wu Su, Josef Pfeuffer, Kamil Ugurbil, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany. Contact e-mail: [email protected] Presentation Number: 544 Noninvasive imaging techniques like MRI possess the prospective to observe mol...
متن کاملCell-penetrating peptides and peptide nucleic acid-coupled MRI contrast agents: evaluation of cellular delivery and target binding.
Molecular imaging of cells and cellular processes can be achieved by tagging intracellular targets such as receptors, enzymes, or mRNA. Seeking to visualize the presence of specific mRNAs by magnetic resonance (MR) imaging, we coupled peptide nucleic acids (PNA) with gadolinium-based MR contrast agents using cell-penetrating peptides for intracellular delivery. Antisense to mRNA of DsRed2 prote...
متن کاملCationic Cell-Penetrating Peptides Are Potent Furin Inhibitors
Cationic cell-penetrating peptides have been widely used to enhance the intracellular delivery of various types of cargoes, such as drugs and proteins. These reagents are chemically similar to the multi-basic peptides that are known to be potent proprotein convertase inhibitors. Here, we report that both HIV-1 TAT47-57 peptide and the Chariot reagent are micromolar inhibitors of furin activity ...
متن کاملCell penetrating and transytosing peptides: powerful strategies for oral insulin delivery
Insulin is essential for type 1 and advanced type 2 diabetes to maintain blood glucose levels and increase the patient’s longevity. Frequent subcutaneous insulin injections are usually associated with pain, local tissue necrosis, infection and nerve damage. Recently, a number of new delivery methods such as oral insulin delivery have been developed to overcome these limitations and increase pa...
متن کاملArginine-rich cell-penetrating peptides.
Arginine-rich cell-penetrating peptides are short cationic peptides capable of traversing the plasma membranes of eukaryotic cells. While successful intracellular delivery of many biologically active macromolecules has been accomplished using these peptides, their mechanisms of cell entry are still under investigation. Recent dialogue has centered on a debate over the roles that direct transloc...
متن کامل